Expert Reactions to Drugs for Neglected Diseases and Impacts of Covid-19 Pandemic

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Dr Monique Wasunna, the Director Drugs for Neglected Diseases initiative (DNDi) Africa, said:

“There are over one billion people affected by Neglected Tropical Diseases (NTDs) worldwide. Approximately 500 million of those affected are children, while at least 1 in 8 people suffer from one of the neglected diseases,”

“Most of the NTDs are a group of preventable and infectious diseases that affect the marginalized and poor populations living in remote areas, urban slums, or conflict zones all over the world. They are generally referred to as neglected diseases owing to the little financial incentive to support desperate need for medical research and innovation to bring news tools to help such cluster of people,”

“As a result of this financial mismatch, about 1.7 billion people worldwide are affected by NTDs. Almost every country worldwide is at least infected by one of the NTDs. At least 40% of the global burden of the NTDs is on African continent,”

“Since NTDs are diseases which are neglected, there are very few treatments that exist for neglected patients. And even if there is, the treatment could be toxic (not safe) and low cure rate and effective yet again with minimal options available to access,”

“Countries in other continents may have the NTDs but fewer compared to Africa with most countries having at least six of NTDs. In the previous years, many researches have been carried out on NTDs were unsuccessful showing lack of research and developments,”

“Before 1991 to 1999 a desk review showed there were 1.1% of at least 1,393 new treatments brought to the market in between 1975 to 1999 were for NTDs representing 12% of the global disease burden. A follow-up 10 years later, thus in 2000 and 2010 another review was done and it showed that 4% of the new drugs were for NTDs,”

“Chemical entity, a drug that started from a scratch and developed gradually through pipelines until it’s ready for human use. So, the new chemical entities were just 1% again showing lack of research and development,”

“Currently there is less than 0.5% of the 88 000 drugs in the global innovation pipeline targeting NTDs even though they represent more than 10% of the global disease burden. About 90% of Research & Development being done are for diseases that affect only 10% of the population hence an ineffectual imbalance. This is reason for DNDi establishment to respond to the frustration of clinicians and the patients,”

“To date DNDi have been developing new treatments for people living with neglected diseases. Thereby acting in the public interest, thus bridges existing R&D gaps in essential drugs for NTDs by initiating and coordinating drug R&D projects in collaboration with the international research community, the public sector, the pharmaceutical industry, and other relevant partners,”

“So, DNDi as none profit drug and research & development organization, aims at saving lives and improving the health of people living with neglected diseases by using an alternative model to develop drugs for these diseases, and by ensuring equitable access to treatment around the world,”

“Since 2007 to date, at least 8 new treatments have so far been delivered by DNDi. For instance:  ASAQ, which isa new combination to simplify malaria treatment (2007), ASMQ for malaria used in Africa and Asia (2008), NECT for sleeping sickness (2009) SSG+PM Visceral leishmaniasis in East Africa (2010), Paediatric benznidazole which is easier and safer treatment for children with Chagas disease (2011), New VL treatment in Asia for supporting disease elimination (2011), Superbooster therapy a more effective treatment for children with HIV who also have TB (2016) and Fexinidazole: a paradigm shift for sleeping sickness(2018),”

“Currently, DNDi is now aiming at a 25 patient-friendly treatments by 2028. By 2025-2027 the target is a radically improved treatment with new chemical entities, all oral for a treatment shift,”

“Misconceptions and myths about NTDs can be a hindrance to effective implementation of control interventions. For example:  NTDs are as a result of witchcraft, NTDs are a punishment from God, NTDs are highly contagious, NTDs affect only a few people, NTDs affect only poor people  in developing countries, NTDs are untreatable among others misconceptions,”

“The truth is that NTDs are caused by a variety of pathogens such as viruses, bacteria, protozoa and parasitic worms. NTDs persist under conditions of poverty and are concentrated in the developing world; most NTDs are not transmitted from person to person, although there are exceptions e.g., Leprosy and Trachoma,”

“Again just to emphasize about 1.7 billion people are affected by at least one NTD, while LMICs are hit the hardest by NTDs, poor people in wealthy nations aren’t immune. e.g., Chagas & Chikungunya in the USA. Many NTDs are treatable with existing drugs. However, many of the treatments are difficult to administer and inaccessible,”

“Instead of going to the hospital patients visit witchdoctors. For examples, lesions for patients with VL, uptake of medicines is suboptimal, and patients face stigma. Those with NTDs are often stigmatized, not enough attention and awareness about the diseases, not enough R&D for NTDs; patients do not seek treatment and are thus greatly impacted by the diseases,”

“With the outbreak of COVID-19, this has affected implementation of health services including NTDs. The main programmatic areas of disruption are: Slowing down of much needed NTD R&D activities, community-based activities, delays in diagnosis, treatment, delays in manufacture, shipment and delivery of NTD medicines, re-assignment of NTD personnel to the COVID-19 response,” “These disruptions could increase burden of NTDs, and delay the achievement of public-health goals and while R&D for vaccines is ongoing, it is important to also focus on finding the best treatment for COVID-19,”